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Last Hosokawa kanrei defeated by Miyoshi Nagayoshi.
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Harumoto became the Kanrei, the deputy shogun, of the Ashikaga shogunate. This position gave him control over the shogunate and made him the most powerful figure in Kyoto.
Harumoto's forces were defeated by Miyoshi Nagayoshi in a series of battles. This led to Harumoto's loss of control over Kyoto and the shogunate, as Nagayoshi seized power.
Harumoto was decisively defeated by Miyoshi Nagayoshi, ending his influence. He was forced to flee and later died, marking the end of the Hosokawa Kanrei line.
See how Hosokawa Harumoto stacks up against other historical figures